TRIP12

Across TCGA cell cohorts, TRIP12 mutation is significantly associated with the RNA expression of many other genes, with 1,919 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIP12-associated genes across cancer lineages are PLEKHM3, OTUD6A, and OR4N2. Each is linked with TRIP12 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIP12-to-partner and partner-to-TRIP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHM3 grouped by TRIP12-low versus TRIP12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIP12→partner) and Y-score (partner→TRIP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLEKHM3 →	+0.384	+2.700	.003	.001	3	3
OESOPHAGUS	OTUD6A →	+0.006	+4.906	<.001	.006	3	2
SOFT_TISSUE	OR4N2 →	+0.084	+3.295	<.001	.006	3	2
OVARY	OR52N5 →	+0.020	+2.974	<.001	.003	3	2
SKIN	C11orf86 →	+0.088	+3.772	<.001	.003	3	2
SKIN	PRAMEF10 →	+0.005	+3.700	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,919 associations by consensus.

PLEKHM3 by TRIP12 expression — LARGE_INTESTINE

Explore this box plot interactively →