TRIP12

Across TCGA pan-cancer cohorts, TRIP12 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TRIP12’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRIP12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIP12 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where TRIP12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIP12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.501	<.001	9	view →
LIHC	All	II,III,IV	+0.745	<.001	8	view →
KICH	Female	All	−1.174	<.001	7	view →
CHOL	Male	All	+1.860	<.001	5	view →
THCA	All	All	−0.308	.004	5	view →
LUAD	Male	All	+0.543	<.001	4	view →
STAD	All	II,III,IV	+0.601	.009	3	view →
ESCA	Female	All	+0.889	.018	2	view →
READ	All	III,IV	+0.750	.038	2	view →
BLCA	Female	All	+0.382	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TRIP12–HNSC

Open the HNSC breakdown →