TRIM60

Across TCGA patient cohorts, TRIM60 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,297 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TRIM60-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase II promoter, Mitochondrial transport, and Regulation of DNA-templated transcription initiation. Each is linked with TRIM60 in more than 10 cancer types. Because this analysis shows association rather than direction, both TRIM60-to-partner and partner-to-TRIM60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase II promoter grouped by TRIM60-low versus TRIM60-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM60→partner) and Y-score (partner→TRIM60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Transcription initiation at RNA polymerase II promoter →	+0.070	+0.191	<.001	<.001	3	11
STAD	Mitochondrial transport →	+0.074	+0.157	<.001	<.001	3	11
STAD	Regulation of DNA-templated transcription initiation →	+0.071	+0.172	<.001	<.001	3	11
STAD	Regulation of protein serine/threonine kinase activity →	+0.059	+0.162	<.001	<.001	3	11
STAD	Regulation of centrosome cycle →	+0.063	+0.149	<.001	<.001	3	10
STAD	DNA-templated transcription initiation →	+0.072	+0.158	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,297 associations by consensus.

Transcription initiation at RNA polymerase II promoter by TRIM60 expression — STAD

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