TRIM60

Across TCGA patient cohorts, TRIM60 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM60-associated genes across cancer lineages are Fibronectin, MSH2, and Raptor. Each is linked with TRIM60 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM60-to-partner and partner-to-TRIM60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by TRIM60-low versus TRIM60-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM60→partner) and Y-score (partner→TRIM60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Fibronectin →	-0.481	-3.000	.020	.034	3	2
SKCM	MSH2 →	+0.224	+1.891	.029	.030	3	2
LUSC	Raptor →	+0.299	+3.009	.007	.019	3	1
COAD	beta-Catenin →	-0.859	-2.991	.011	.036	3	1
UCEC	p27_pT198 →	+0.144	+3.321	.003	.010	3	1
UCEC	STAT3_pY705 →	-0.392	-2.311	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Fibronectin by TRIM60 expression — SKCM

Explore this box plot interactively →