TRIM60

Across TCGA cell cohorts, TRIM60 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRIM60-associated genes across cancer lineages are ENTHD1, FAM205A, and TMEM82. Each is linked with TRIM60 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM60-to-partner and partner-to-TRIM60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENTHD1 grouped by TRIM60-low versus TRIM60-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM60→partner) and Y-score (partner→TRIM60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ENTHD1 →	+0.053	+4.285	<.001	.003	3	1
LARGE_INTESTINE	FAM205A →	+0.016	+3.029	<.001	.002	3	1
BLOOD_Lymphoma	TMEM82 →	+0.024	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	OR6C76 →	+0.047	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP1-4 →	+0.067	+5.247	<.001	.001	3	1
LUNG_NSCLC_LUAD	GPHB5 →	+0.039	+4.887	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ENTHD1 by TRIM60 expression — BLOOD_Myeloma

Explore this box plot interactively →