TRIM6-TRIM34

Across TCGA patient cohorts, TRIM6-TRIM34 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,330 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible TRIM6-TRIM34-associated GO terms across cancer lineages are Canonical NF-kappaB signal transduction, Receptor catabolic process, and Negative regulation of autophagosome assembly. Each is linked with TRIM6-TRIM34 in more than 9 cancer types. Because this analysis shows association rather than direction, both TRIM6-TRIM34-to-partner and partner-to-TRIM6-TRIM34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Canonical NF-kappaB signal transduction grouped by TRIM6-TRIM34-low versus TRIM6-TRIM34-high in LGG.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM6-TRIM34→partner) and Y-score (partner→TRIM6-TRIM34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	Canonical NF-kappaB signal transduction →	+0.024	+0.003	<.001	<.001	3	10
LIHC	Receptor catabolic process →	+0.037	+0.006	<.001	<.001	3	10
LGG	Negative regulation of autophagosome assembly →	+0.045	+0.002	<.001	.001	3	9
PAAD	Autophagosome organization →	+0.031	+0.004	<.001	.001	3	9
PRAD	Ribosome-associated ubiquitin-dependent protein catabolic process →	+0.047	+0.002	<.001	<.001	3	9
PRAD	Response to acid chemical →	+0.028	+0.003	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,330 associations by consensus.

Canonical NF-kappaB signal transduction by TRIM6-TRIM34 expression — LGG

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