TRIM6-TRIM34

Across TCGA patient cohorts, TRIM6-TRIM34 mutation is significantly associated with the RNA expression of many other genes, with 1,385 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM6-TRIM34-associated genes across cancer lineages are RN7SL134P, TIPIN, and HMX3. Each is linked with TRIM6-TRIM34 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM6-TRIM34-to-partner and partner-to-TRIM6-TRIM34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by TRIM6-TRIM34-low versus TRIM6-TRIM34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM6-TRIM34→partner) and Y-score (partner→TRIM6-TRIM34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.112	+2.097	<.001	.005	3	3
UCEC	TIPIN →	+0.437	+2.269	.002	.001	3	3
LUSC	HMX3 →	+1.020	+3.870	<.001	.004	3	2
LUSC	RNU6-940P →	+0.224	+4.578	<.001	.005	3	2
LUSC	KRTAP12-2 →	+0.063	+4.474	.005	.001	3	2
LUSC	CDH12P1 →	+0.180	+4.978	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,385 associations by consensus.

RN7SL134P by TRIM6-TRIM34 expression — UCEC

Explore this box plot interactively →