TRIM6-TRIM34

Across TCGA patient cohorts, TRIM6-TRIM34 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM6-TRIM34-associated genes across cancer lineages are MEK1, PCNA, and ATM. Each is linked with TRIM6-TRIM34 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM6-TRIM34-to-partner and partner-to-TRIM6-TRIM34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TRIM6-TRIM34-low versus TRIM6-TRIM34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM6-TRIM34→partner) and Y-score (partner→TRIM6-TRIM34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.434	+2.700	.003	.005	3	2
UCEC	PCNA →	+0.213	+1.906	.014	.016	3	2
UCEC	ATM →	-0.383	-1.906	.035	.016	3	2
UCEC	BRD4 →	+0.314	+3.459	.003	.004	3	2
UCEC	Caspase-7-cleavedD198 →	+1.031	+2.926	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.742	+2.415	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MEK1 by TRIM6-TRIM34 expression — UCEC

Explore this box plot interactively →