TRIM53BP

Across TCGA patient cohorts, TRIM53BP mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRIM53BP-associated genes across cancer lineages are SLC25A5P4, LINC02559, and NMBR-AS1. Each is linked with TRIM53BP in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM53BP-to-partner and partner-to-TRIM53BP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A5P4 grouped by TRIM53BP-low versus TRIM53BP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM53BP→partner) and Y-score (partner→TRIM53BP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SLC25A5P4 →	+0.059	+4.661	<.001	.004	3	1
SKCM	LINC02559 →	+0.196	+5.624	<.001	.002	3	1
SKCM	NMBR-AS1 →	+0.161	+4.513	<.001	.009	3	1
SKCM	RN7SL310P →	+0.114	+5.080	<.001	.004	3	1
SKCM	RPL39P31 →	+0.210	+4.680	<.001	.007	3	1
SKCM	ACTR3P3 →	+0.038	+4.594	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

SLC25A5P4 by TRIM53BP expression — SKCM

Explore this box plot interactively →