TRIM51HP

Across TCGA patient cohorts, TRIM51HP mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM51HP-associated genes across cancer lineages are PCNA, Cyclin-B1, and ATM. Each is linked with TRIM51HP in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM51HP-to-partner and partner-to-TRIM51HP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TRIM51HP-low versus TRIM51HP-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM51HP→partner) and Y-score (partner→TRIM51HP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PCNA →	+0.274	+2.334	<.001	.018	3	3
LUAD	Cyclin-B1 →	+0.704	+2.000	<.001	.031	3	3
UCEC	ATM →	-0.602	-3.156	.002	.018	3	3
LUAD	PKC-b-II_pS660 →	-0.394	-3.169	.019	.018	3	2
LUAD	Bap1-c-4 →	+0.189	+2.016	.020	.018	3	2
LUAD	Bim →	+0.543	+2.824	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

PCNA by TRIM51HP expression — LUAD

Explore this box plot interactively →