Across TCGA patient cohorts, TRIM49C mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM49C-associated genes across cancer lineages are Tuberin, Rictor_pT1135, and JNK2. Each is linked with TRIM49C in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM49C-to-partner and partner-to-TRIM49C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM49C→partner) and Y-score (partner→TRIM49C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Tuberin →	+0.332	+3.169	.036	.019	3	2
UCEC	Rictor_pT1135 →	-0.099	-2.321	.026	.034	3	2
UCEC	JNK2 →	+0.212	+2.115	.014	.019	3	1
UCEC	STAT3_pY705 →	-0.387	-2.321	<.001	.033	3	1
UCEC	Caspase-8 →	-0.238	-3.558	.030	.002	3	1
LUAD	NF-kB-p65_pS536 →	+0.641	+3.186	.002	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

TRIM49C survival (RNA) · tumor vs normal (RNA) · all TRIM49C data types