Across TCGA pan-cancer cohorts, TRIM49C RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated TRIM49C data layer compared with 9 for mutation status.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher TRIM49C RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRIM49C expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.
BLCA, LUSC, and UCEC are the cancer types where TRIM49C RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.