Across TCGA pan-cancer cohorts, TRIM49C RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TRIM49C’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TRIM49C RNA is repressed in tumor relative to normal tissue. In most cancer types TRIM49C is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, LUAD, and LUSC are the cancer types where TRIM49C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRIM49C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.011	.041	2	view →
LUAD	Male	All	+0.021	.042	1	view →
LUSC	All	II,III,IV	+0.012	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TRIM49C RNA expression & survival · all TRIM49C data types