Across TCGA cell cohorts, TRIM49C mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TRIM49C-associated genes across cancer lineages are AMELX, TAAR5, and OR10K1. Each is linked with TRIM49C in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM49C-to-partner and partner-to-TRIM49C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM49C→partner) and Y-score (partner→TRIM49C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AMELX →	+0.090	+4.256	<.001	.002	3	1
LUNG_SCLC	TAAR5 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	OR10K1 →	+0.344	+4.614	<.001	<.001	3	1
LUNG_SCLC	OR10K2 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	OR6Y1 →	+0.004	+4.058	<.001	.007	3	1
LUNG_SCLC	OR2T11 →	+0.018	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

TRIM49C survival (RNA) · tumor vs normal (RNA) · all TRIM49C data types