TRIM49

Across TCGA patient cohorts, TRIM49 mutation is significantly associated with the RNA expression of many other genes, with 2,529 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM49-associated genes across cancer lineages are RNU6ATAC17P, NDUFA4P2, and GAPDHP50. Each is linked with TRIM49 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRIM49-to-partner and partner-to-TRIM49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6ATAC17P grouped by TRIM49-low versus TRIM49-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM49→partner) and Y-score (partner→TRIM49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6ATAC17P →	+0.424	+2.911	.006	.002	3	3
COAD	NDUFA4P2 →	+0.328	+4.020	<.001	.002	3	3
COAD	GAPDHP50 →	+0.206	+3.942	<.001	.002	3	3
LUSC	FEN1P1 →	+0.061	+2.910	.006	.005	3	2
LUSC	ILRUNP1 →	+0.090	+2.937	.008	.003	3	2
COAD	SMARCE1P3 →	+0.260	+3.815	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,529 associations by consensus.

RNU6ATAC17P by TRIM49 expression — LUAD

Explore this box plot interactively →