Across TCGA pan-cancer cohorts, TRIM49 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of TRIM49’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where TRIM49 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRIM49 is over-expressed in tumor.
LUSC are the cancer types where TRIM49 tumor–normal differential expression is most reproducible.