TRIM43

Across TCGA patient cohorts, TRIM43 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM43-associated genes across cancer lineages are Cyclin-B1, MEK1, and Di-Ras3. Each is linked with TRIM43 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM43-to-partner and partner-to-TRIM43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TRIM43-low versus TRIM43-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM43→partner) and Y-score (partner→TRIM43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.921	+3.169	.002	.020	2	1
UCEC	MEK1 →	+0.568	+3.169	.004	.020	1	1
UCEC	Di-Ras3 →	-0.203	-3.169	.012	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Cyclin-B1 by TRIM43 expression — UCEC

Explore this box plot interactively →