TRIM39-RPP21

Across TCGA patient cohorts, TRIM39-RPP21 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM39-RPP21-associated genes across cancer lineages are ELOCP14, RNA5SP493, and RN7SKP214. Each is linked with TRIM39-RPP21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM39-RPP21-to-partner and partner-to-TRIM39-RPP21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOCP14 grouped by TRIM39-RPP21-low versus TRIM39-RPP21-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM39-RPP21→partner) and Y-score (partner→TRIM39-RPP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ELOCP14 →	+0.104	+7.816	<.001	.008	3	1
UCEC	RNA5SP493 →	+0.510	+3.105	.007	.005	3	1
UCEC	RN7SKP214 →	+0.298	+3.071	.001	.004	3	1
UCEC	KRTAP20-3 →	+0.155	+5.475	<.001	.001	3	1
UCEC	RNU6-206P →	+0.275	+4.660	<.001	.003	3	1
UCEC	MIR128-2 →	+0.257	+4.464	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ELOCP14 by TRIM39-RPP21 expression — SKCM

Explore this box plot interactively →