TRIM39-RPP21

Across TCGA pan-cancer cohorts, TRIM39-RPP21 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated TRIM39-RPP21 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TRIM39-RPP21 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRIM39-RPP21 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

KIRP, UCEC, and BLCA are the cancer types where TRIM39-RPP21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	IV	0.087	0.580	.006	37	view →
UCEC	DFS	Median	II,III,IV	0.609	0.806	<.001	36	view →
BLCA	DFS	Quartile	All	0.480	0.248	.012	21	view →
LGG	DFS	Quartile	All	0.668	0.875	.001	18	view →
LUSC	DFS	Quartile	III,IV	0.229	0.778	.002	16	view →
LUAD	DFS	Tertile	All	0.721	0.834	.006	12	view →
COAD	DFS	Median	All	0.378	0.604	.021	8	view →
UVM	DFS	Tertile	III,IV	0.205	0.739	.018	8	view →
SKCM	OS	Median	II,III,IV	0.504	0.229	.025	7	view →
CHOL	OS	Median	II,III,IV	0.080	0.740	.026	6	view →
THYM	DFS	Tertile	III,IV	0.214	1.000	.017	6	view →
CESC	OS	Median	II,III,IV	0.896	0.765	.029	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

TRIM39-RPP21–KIRP (DFS)

Open the KIRP breakdown →