TRIM16L

Across TCGA patient cohorts, TRIM16L mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRIM16L-associated genes across cancer lineages are PDCD4, EGFR_pY1068, and MEK1. Each is linked with TRIM16L in more than 1 cancer types. Because this analysis shows association rather than direction, both TRIM16L-to-partner and partner-to-TRIM16L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TRIM16L-low versus TRIM16L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRIM16L→partner) and Y-score (partner→TRIM16L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.823	-2.321	<.001	.035	3	2
UCEC	EGFR_pY1068 →	-0.256	-2.321	.042	.035	3	1
UCEC	MEK1 →	+0.381	+2.321	.038	.035	3	1
UCEC	ATM →	-0.700	-3.459	.002	.005	3	1
UCEC	STAT3_pY705 →	-0.534	-3.459	<.001	.005	2	1
UCEC	TFRC →	+0.802	+3.000	.002	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PDCD4 by TRIM16L expression — UCEC

Explore this box plot interactively →