TRHR

Across TCGA cell cohorts, TRHR mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRHR-associated genes across cancer lineages are C6orf118, ACSM6, and IL5. Each is linked with TRHR in more than 1 cancer types. Because this analysis shows association rather than direction, both TRHR-to-partner and partner-to-TRHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by TRHR-low versus TRHR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRHR→partner) and Y-score (partner→TRHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.169	<.001	.007	3	1
SKIN	IL5 →	+0.124	+4.257	.001	<.001	3	1
SKIN	PRY →	+0.599	+3.520	<.001	.005	3	1
SKIN	C18orf63 →	+0.005	+3.700	<.001	.009	3	1
BLOOD_Leukemia	CRYGC →	+0.020	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C6orf118 by TRHR expression — LARGE_INTESTINE

Explore this box plot interactively →