TRHR

Across TCGA pan-cancer cohorts, TRHR RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRHR’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TRHR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRHR is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.

THCA, LUSC, and BRCA are the cancer types where TRHR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRHR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	+0.359	<.001	6	view →
LUSC	All	All	+0.038	.028	2	view →
BRCA	All	III,IV	−0.031	.023	2	view →
KIRC	All	All	+0.016	.008	2	view →
COAD	All	III,IV	−0.021	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TRHR–THCA

Open the THCA breakdown →