TRHR

Across TCGA pan-cancer cohorts, TRHR RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TRHR data layer compared with 7 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TRHR RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRHR expression acts as an unfavorable survival marker, although some lineages such as SCLC and GBM show a favorable association.

SCLC, LGG, and THYM are the cancer types where TRHR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Tertile	II,III,IV	0.561	0.252	.011	43	view →
LGG	OS	Quartile	All	0.382	0.634	<.001	36	view →
THYM	OS	Tertile	II,III,IV	0.534	0.970	<.001	36	view →
UCEC	DFS	Tertile	All	0.454	0.678	.004	36	view →
UVM	DFS	Tertile	All	0.079	0.746	<.001	27	view →
READ	OS	Tertile	IV	0.111	0.893	<.001	27	view →
MESO	OS	Tertile	II,III,IV	0.271	0.623	.012	24	view →
TGCT	OS	Tertile	II,III,IV	0.802	1.000	.040	18	view →
LUAD	DFS	Tertile	II,III,IV	0.525	0.700	.012	18	view →
COAD	OS	Tertile	IV	0.223	0.682	.001	18	view →
PCPG	DFS	Tertile	All	0.778	0.908	.035	15	view →
GBM	DFS	Median	All	0.276	0.160	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

TRHR–SCLC (DFS)

Open the SCLC breakdown →