Across TCGA patient cohorts, TREX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 556 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible TREX1-associated GO terms across cancer lineages are Regulation of triglyceride biosynthetic process, Mitochondrial gene expression, and Interferon-mediated signaling pathway. Each is linked with TREX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREX1-to-partner and partner-to-TREX1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX1→partner) and Y-score (partner→TREX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Regulation of triglyceride biosynthetic process →	+0.085	+0.497	<.001	.002	3	1
SCLC	Mitochondrial gene expression →	-0.072	-0.787	.001	.002	3	1
SCLC	Interferon-mediated signaling pathway →	+0.122	+0.847	.001	.001	3	1
SCLC	RNA methylation →	-0.048	-0.676	<.001	<.001	3	1
SCLC	Fructose transmembrane transport →	+0.638	+0.526	<.001	.001	3	1
SCLC	Cytidine to uridine editing →	+0.631	+0.708	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 556 associations by consensus.

Exploration

TREX1 survival (RNA) · tumor vs normal (RNA) · all TREX1 data types