Across TCGA pan-cancer cohorts, TREX1 RNA is linked to patient survival in 1 of 34 cancer types, making it a survival-associated TREX1 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TREX1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TREX1 expression acts as an unfavorable survival marker, although some lineages such as SCLC show a favorable association.

SCLC are the cancer types where TREX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.933	0.636	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: TREX1 tumor-vs-normal RNA expression · all TREX1 data types