Across TCGA patient cohorts, TREX1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,532 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TREX1-associated genes across cancer lineages are ISG15, OAS2, and IFIT3. Each is linked with TREX1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TREX1-to-partner and partner-to-TREX1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX1→partner) and Y-score (partner→TREX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ISG15 →	+1.754	+0.407	<.001	<.001	3	6
HNSC	OAS2 →	+1.234	+0.276	<.001	<.001	3	5
HNSC	IFIT3 →	+1.509	+0.246	<.001	<.001	3	5
HNSC	IFIT2 →	+1.469	+0.282	<.001	<.001	3	5
COAD	SLC15A3 →	+0.956	+0.498	<.001	<.001	3	4
COAD	BIN2 →	+0.791	+0.443	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,532 associations by consensus.

Exploration

TREX1 survival (RNA) · tumor vs normal (RNA) · all TREX1 data types