Across TCGA patient cohorts, TREX1 protein abundance is significantly associated with the protein abundance of many other proteins, with 13,132 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible TREX1-associated proteins across cancer lineages are OAS2, TREX1_S167, and IFIT1. Each is linked with TREX1 in more than 7 cancer types. Because this analysis shows association rather than direction, both TREX1-to-partner and partner-to-TREX1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX1→partner) and Y-score (partner→TREX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OAS2 →	+0.737	+0.395	<.001	<.001	3	8
COAD	TREX1_S167 →	+0.743	+0.424	.003	.001	2	8
HNSC	IFIT1 →	+0.638	+0.231	<.001	<.001	3	6
HNSC	GIMAP1 →	+0.588	+0.375	<.001	<.001	3	6
HNSC	MX2 →	+0.627	+0.241	<.001	<.001	3	5
COAD	HLA-E →	+0.535	+0.353	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,132 associations by consensus.

Exploration

TREX1 survival (RNA) · tumor vs normal (RNA) · all TREX1 data types