Across TCGA cell cohorts, TREX1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TREX1-associated genes across cancer lineages are TBC1D21, C12orf40, and TAFA1. Each is linked with TREX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREX1-to-partner and partner-to-TREX1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREX1→partner) and Y-score (partner→TREX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	C12orf40 →	+0.011	+4.684	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.402	+4.273	<.001	.006	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
LARGE_INTESTINE	DEFA3 →	+0.076	+4.415	<.001	.007	3	1
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

TREX1 survival (RNA) · tumor vs normal (RNA) · all TREX1 data types