Across TCGA patient cohorts, TREML4 mutation is significantly associated with the RNA expression of many other genes, with 280 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TREML4-associated genes across cancer lineages are MFSD12, PIAS4, and SLC39A3. Each is linked with TREML4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TREML4-to-partner and partner-to-TREML4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TREML4→partner) and Y-score (partner→TREML4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MFSD12 →	+1.331	+3.604	<.001	.001	3	2
UCEC	PIAS4 →	+0.432	+3.332	.006	.005	3	2
UCEC	SLC39A3 →	+0.611	+3.354	.002	.005	3	2
SKCM	RNU6-3P →	+0.271	+2.155	.002	.007	3	2
SKCM	KRT18P51 →	+0.101	+2.332	<.001	.008	3	1
SKCM	RNA5SP461 →	+0.120	+5.357	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 280 associations by consensus.

Exploration

TREML4 survival (RNA) · tumor vs normal (RNA) · all TREML4 data types