TRBV5-4

Across TCGA patient cohorts, TRBV5-4 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,521 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TRBV5-4-associated proteins across cancer lineages are HCLS1, SEPTIN1, and SEPTIN1_S206. Each is linked with TRBV5-4 in more than 8 cancer types. Because this analysis shows association rather than direction, both TRBV5-4-to-partner and partner-to-TRBV5-4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRBV5-4 versus HCLS1 in HNSC, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV5-4→partner) and Y-score (partner→TRBV5-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HCLS1 →	+0.573	+0.717	<.001	<.001	3	9
BRCA	SEPTIN1 →	+0.915	+1.222	<.001	<.001	3	9
HNSC	SEPTIN1_S206 →	+1.280	+0.745	<.001	<.001	3	8
HNSC	EVL →	+0.698	+0.771	<.001	<.001	3	8
LSCC	IKZF1 →	+0.654	+0.832	<.001	<.001	3	8
GBM	IKZF1_S63 →	+0.840	+0.301	.001	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,521 associations by consensus.

TRBV5-4 vs HCLS1 — HNSC

Explore this scatter interactively →