TRBV5-4

Across TCGA pan-cancer cohorts, TRBV5-4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TRBV5-4 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher TRBV5-4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRBV5-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

UVM, HNSC, and SKCM are the cancer types where TRBV5-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.408	0.727	<.001	105	view →
HNSC	DFS	Tertile	All	0.768	0.635	<.001	96	view →
SKCM	OS	Median	All	0.427	0.275	<.001	89	view →
BRCA	DFS	Median	All	0.598	0.464	<.001	74	view →
LUAD	DFS	Tertile	All	0.746	0.591	<.001	60	view →
CESC	OS	Tertile	All	0.873	0.731	.006	56	view →
ACC	DFS	Median	All	0.746	0.477	.004	32	view →
ESCA	DFS	Tertile	III,IV	0.531	0.202	<.001	21	view →
UCEC	DFS	Quartile	IV	0.772	0.294	.015	20	view →
LIHC	DFS	Quartile	All	0.570	0.346	.004	19	view →
KIRC	DFS	Median	II,III,IV	0.612	0.383	.015	18	view →
KIRP	DFS	Quartile	III,IV	0.372	0.829	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TRBV5-4–UVM (OS)

Open the UVM breakdown →