TRBV5-4

Across TCGA pan-cancer cohorts, TRBV5-4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of TRBV5-4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV5-4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV5-4 is over-expressed in tumor, although a few such as PAAD and LUSC show the opposite, repressed pattern.

KIRC, BRCA, and PAAD are the cancer types where TRBV5-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV5-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.030	<.001	10	view →
BRCA	All	All	+0.263	.013	4	view →
PAAD	All	All	−1.417	.037	2	view →
STAD	Female	All	+1.134	.012	2	view →
LUSC	Male	III,IV	−1.069	.029	1	view →
CHOL	All	All	+0.824	.037	1	view →
KICH	Female	All	−0.350	.015	1	view →
COAD	Female	All	−0.296	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

TRBV5-4–KIRC

Open the KIRC breakdown →