TRBV30

Across TCGA patient cohorts, TRBV30 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRBV30-associated genes across cancer lineages are MTATP6P7, MIR378E, and GMCL1P2. Each is linked with TRBV30 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV30-to-partner and partner-to-TRBV30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P7 grouped by TRBV30-low versus TRBV30-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV30→partner) and Y-score (partner→TRBV30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MTATP6P7 →	+0.097	+5.309	<.001	.003	3	2
UCEC	MIR378E →	+0.608	+4.453	<.001	.006	3	1
UCEC	GMCL1P2 →	+0.308	+3.821	.003	.005	3	1
UCEC	MIR98 →	+0.541	+3.801	<.001	.004	3	1
UCEC	MIR8055 →	+0.845	+3.643	.004	.008	3	1
UCEC	CICP28 →	+0.035	+4.351	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MTATP6P7 by TRBV30 expression — LUSC

Explore this box plot interactively →