TRBV30

Across TCGA pan-cancer cohorts, TRBV30 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TRBV30 data layer compared with 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV30 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV30 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BLCA are the cancer types where TRBV30 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.752	0.638	<.001	138	view →
SKCM	OS	Median	All	0.835	0.726	<.001	136	view →
BLCA	DFS	Tertile	All	0.425	0.206	<.001	91	view →
CESC	OS	Quartile	All	0.906	0.714	.001	56	view →
LGG	DFS	Quartile	All	0.624	0.766	<.001	36	view →
LUAD	OS	Median	All	0.893	0.776	<.001	29	view →
UCS	DFS	Median	III,IV	0.518	0.164	.016	22	view →
BRCA	OS	Median	All	0.971	0.953	.007	20	view →
THYM	OS	Median	II,III,IV	0.962	0.683	.003	19	view →
ACC	DFS	Tertile	All	0.782	0.332	.022	14	view →
ESCA	DFS	Tertile	IV	0.242	0.692	.024	12	view →
KICH	DFS	Tertile	All	0.594	1.000	.014	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TRBV30–HNSC (DFS)

Open the HNSC breakdown →