TRBV3-1

Across TCGA patient cohorts, TRBV3-1 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRBV3-1-associated genes across cancer lineages are OR8B5P, EGLN3-AS1, and MIR5682. Each is linked with TRBV3-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV3-1-to-partner and partner-to-TRBV3-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B5P grouped by TRBV3-1-low versus TRBV3-1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV3-1→partner) and Y-score (partner→TRBV3-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR8B5P →	+0.056	+3.180	<.001	.004	3	1
SKCM	EGLN3-AS1 →	+0.245	+4.702	<.001	<.001	3	1
SKCM	MIR5682 →	+0.190	+4.634	<.001	.003	3	1
SKCM	RN7SL703P →	+0.129	+4.867	<.001	<.001	3	1
SKCM	RN7SL524P →	+0.117	+3.216	<.001	.004	3	1
BLCA	RNU6-982P →	+0.236	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

OR8B5P by TRBV3-1 expression — SKCM

Explore this box plot interactively →