TRBV3-1

Across TCGA pan-cancer cohorts, TRBV3-1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TRBV3-1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV3-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV3-1 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where TRBV3-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV3-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.355	<.001	11	view →
COAD	All	IV	−1.134	<.001	11	view →
LUSC	All	All	−0.473	.002	5	view →
BRCA	All	All	+0.286	.015	4	view →
ESCA	All	II,III,IV	+1.300	.016	3	view →
READ	All	II,III,IV	−1.267	.035	2	view →
BLCA	Female	All	−1.242	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TRBV3-1–KIRC

Open the KIRC breakdown →