TRBV3-1

Across TCGA pan-cancer cohorts, TRBV3-1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TRBV3-1 data layer compared with 1 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TRBV3-1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRBV3-1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and BRCA are the cancer types where TRBV3-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.408	0.277	<.001	116	view →
HNSC	DFS	Median	All	0.745	0.645	<.001	114	view →
BRCA	DFS	Median	II,III,IV	0.582	0.461	<.001	89	view →
LUAD	DFS	Median	All	0.842	0.738	<.001	70	view →
UVM	OS	Quartile	All	0.343	0.761	<.001	67	view →
CESC	OS	Median	All	0.924	0.818	.001	58	view →
COAD	DFS	Median	All	0.786	0.604	.002	38	view →
BLCA	OS	Tertile	IV	0.712	0.494	.004	35	view →
KIRP	DFS	Tertile	III,IV	0.129	0.605	.004	35	view →
ACC	DFS	Tertile	II,III,IV	0.703	0.268	.013	32	view →
OV	OS	Median	IV	0.708	0.532	.011	18	view →
CHOL	DFS	Median	All	0.586	0.221	.011	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TRBV3-1–SKCM (OS)

Open the SKCM breakdown →