TRBV29-1

Across TCGA patient cohorts, TRBV29-1 mutation is significantly associated with the RNA expression of many other genes, with 185 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRBV29-1-associated genes across cancer lineages are MIR1305, MIR133B, and PDAP1. Each is linked with TRBV29-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV29-1-to-partner and partner-to-TRBV29-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1305 grouped by TRBV29-1-low versus TRBV29-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV29-1→partner) and Y-score (partner→TRBV29-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1305 →	+0.335	+3.997	<.001	.009	3	2
SKCM	MIR133B →	+0.619	+4.408	<.001	<.001	3	2
SKCM	PDAP1 →	+0.588	+3.465	<.001	.003	3	2
SKCM	LINC00604 →	+0.086	+2.766	<.001	.006	3	1
SKCM	MRPS35P2 →	+0.063	+4.163	<.001	.006	3	1
SKCM	DBIP2 →	+0.153	+2.656	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 185 associations by consensus.

MIR1305 by TRBV29-1 expression — UCEC

Explore this box plot interactively →