TRBV29-1

Across TCGA pan-cancer cohorts, TRBV29-1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated TRBV29-1 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV29-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV29-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where TRBV29-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.392	0.245	<.001	134	view →
SKCM	OS	Median	All	0.840	0.720	<.001	125	view →
BRCA	DFS	Median	All	0.647	0.450	<.001	83	view →
CESC	OS	Tertile	All	0.874	0.688	<.001	70	view →
LUAD	DFS	Tertile	All	0.851	0.731	<.001	40	view →
UVM	DFS	Tertile	All	0.554	0.886	.002	38	view →
LGG	OS	Tertile	All	0.813	0.933	<.001	30	view →
LIHC	DFS	Quartile	All	0.635	0.451	.003	23	view →
THYM	OS	Median	All	1.000	0.745	.001	16	view →
SARC	OS	Tertile	All	0.852	0.651	<.001	15	view →
KIRP	DFS	Quartile	All	0.539	1.000	.015	15	view →
THCA	DFS	Quartile	IV	0.865	0.440	.022	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

TRBV29-1–HNSC (DFS)

Open the HNSC breakdown →