TRAV1-1

Across TCGA patient cohorts, TRAV1-1 RNA expression is significantly associated with the mutation status of many other genes, with 8,654 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAV1-1-associated genes across cancer lineages are SMARCAL1, TTN, and ADGRG4. Each is linked with TRAV1-1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAV1-1-to-partner and partner-to-TRAV1-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMARCAL1 grouped by TRAV1-1-low versus TRAV1-1-high in UCEC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV1-1→partner) and Y-score (partner→TRAV1-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMARCAL1 →	+1.780	+0.221	<.001	.006	3	3
LIHC	TTN →	-0.933	-0.153	<.001	<.001	3	3
UCEC	ADGRG4 →	+1.341	+0.290	<.001	<.001	3	3
UCEC	IKZF1 →	+1.568	+0.291	<.001	<.001	3	3
SKCM	FN1 →	-3.329	-0.385	.005	.005	3	2
SKCM	CENPF →	-1.933	-0.361	.009	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,654 associations by consensus.

SMARCAL1 by TRAV1-1 expression — UCEC

Explore this box plot interactively →