TRAP1

Across TCGA patient cohorts, TRAP1 mutation is significantly associated with the RNA expression of many other genes, with 2,670 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAP1-associated genes across cancer lineages are SFXN1, GLOD4, and PABPC1L2B-AS1. Each is linked with TRAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAP1-to-partner and partner-to-TRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFXN1 grouped by TRAP1-low versus TRAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAP1→partner) and Y-score (partner→TRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SFXN1 →	+0.489	+3.928	<.001	<.001	3	3
UCEC	GLOD4 →	+0.452	+2.654	<.001	<.001	3	3
COAD	PABPC1L2B-AS1 →	+0.015	+4.734	<.001	.002	3	3
READ	LINC02825 →	+0.087	+5.653	<.001	.003	3	2
UCEC	TUBGCP5 →	+0.414	+3.218	<.001	<.001	3	2
UCEC	UHRF1 →	+0.747	+2.711	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,670 associations by consensus.

SFXN1 by TRAP1 expression — UCEC

Explore this box plot interactively →