TRAP1

Across TCGA pan-cancer cohorts, TRAP1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRAP1 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher TRAP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRAP1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

UVM, KIRC, and COAD are the cancer types where TRAP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.402	0.769	<.001	81	view →
KIRC	OS	Tertile	All	0.743	0.543	<.001	43	view →
COAD	OS	Quartile	All	0.939	0.783	.005	41	view →
READ	OS	Median	III,IV	1.000	0.434	.002	36	view →
LAML	DFS	Quartile	All	0.332	0.705	.002	36	view →
LGG	DFS	Median	All	0.805	0.663	<.001	35	view →
LIHC	DFS	Median	All	0.474	0.608	<.001	26	view →
ACC	DFS	Median	III,IV	0.574	0.120	.001	23	view →
BLCA	OS	Quartile	II,III,IV	0.615	0.750	.011	23	view →
BRCA	DFS	Tertile	III,IV	0.929	0.825	.006	20	view →
MESO	DFS	Median	IV	0.155	0.498	<.001	18	view →
THCA	DFS	Quartile	IV	0.379	0.968	.006	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TRAP1–UVM (DFS)

Open the UVM breakdown →