TRAP1

Across TCGA patient cohorts, TRAP1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAP1-associated genes across cancer lineages are ASNS, PKC-a, and PREX1. Each is linked with TRAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAP1-to-partner and partner-to-TRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TRAP1-low versus TRAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAP1→partner) and Y-score (partner→TRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.331	+1.584	.009	.034	3	2
COAD	PKC-a →	-0.425	-3.161	.002	.019	3	1
COAD	PREX1 →	+0.409	+2.840	<.001	.033	3	1
COAD	Stathmin →	+0.323	+3.178	<.001	.010	3	1
COAD	BRCA2 →	+0.282	+3.000	.020	.036	3	1
UCEC	eIF4E →	+0.194	+3.472	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ASNS by TRAP1 expression — UCEC

Explore this box plot interactively →