TRAF4

Across TCGA cell cohorts, TRAF4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible TRAF4-associated genes across cancer lineages are C12orf54, C6orf118, and OR1L3. Each is linked with TRAF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF4-to-partner and partner-to-TRAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf54 grouped by TRAF4-low versus TRAF4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF4→partner) and Y-score (partner→TRAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C12orf54 →	+0.090	+4.347	<.001	.001	3	2
LARGE_INTESTINE	C6orf118 →	+0.104	+3.793	.005	.007	3	1
LARGE_INTESTINE	OR1L3 →	+0.020	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	OR2J3 →	+0.044	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OR5V1 →	+0.008	+4.437	<.001	.004	3	1
STOMACH	CYP11B2 →	+0.005	+4.285	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

C12orf54 by TRAF4 expression — LARGE_INTESTINE

Explore this box plot interactively →