TRADD

Across TCGA cell cohorts, TRADD mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRADD-associated genes across cancer lineages are OR2M5, OR52A5, and NPAP1. Each is linked with TRADD in more than 1 cancer types. Because this analysis shows association rather than direction, both TRADD-to-partner and partner-to-TRADD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by TRADD-low versus TRADD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRADD→partner) and Y-score (partner→TRADD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	OR52A5 →	+0.006	+6.022	<.001	.001	3	1
LARGE_INTESTINE	NPAP1 →	+0.006	+6.022	<.001	.001	3	1
LARGE_INTESTINE	LCE4A →	+0.093	+6.022	<.001	.001	3	1
LARGE_INTESTINE	IFNA14 →	+0.046	+6.022	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

OR2M5 by TRADD expression — LARGE_INTESTINE

Explore this box plot interactively →