TRADD

Across TCGA pan-cancer cohorts, TRADD RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TRADD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRADD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRADD is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where TRADD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRADD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.596	<.001	12	view →
HNSC	Male	III,IV	+0.795	<.001	10	view →
KIRP	Male	II,III,IV	+0.774	<.001	9	view →
LIHC	Female	All	+0.938	<.001	8	view →
COAD	Female	All	+0.461	<.001	8	view →
BLCA	All	All	+0.739	.001	7	view →
LUAD	All	All	+0.287	<.001	6	view →
CHOL	All	All	+1.941	<.001	5	view →
KICH	All	All	−0.632	<.001	5	view →
STAD	All	All	+0.489	.009	3	view →
ESCA	All	All	+0.638	.004	2	view →
UCEC	All	All	−0.527	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TRADD–KIRC

Open the KIRC breakdown →