TRADD

Across TCGA pan-cancer cohorts, TRADD RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TRADD data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher TRADD RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRADD expression acts as an unfavorable survival marker, although some lineages such as KIRP and UCEC show a favorable association.

LGG, KIRP, and UCEC are the cancer types where TRADD RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.326	0.536	<.001	54	view →
KIRP	DFS	Median	II,III,IV	0.900	0.637	<.001	35	view →
UCEC	DFS	Quartile	All	0.787	0.629	.006	32	view →
SARC	OS	Tertile	All	0.914	0.725	<.001	26	view →
READ	DFS	Tertile	All	0.557	0.845	.001	24	view →
ESCA	DFS	Tertile	All	1.000	0.521	.011	24	view →
BRCA	OS	Tertile	IV	0.277	0.820	.006	22	view →
KIRC	DFS	Median	III,IV	0.744	0.522	.004	20	view →
LAML	DFS	Quartile	All	0.376	0.647	.003	16	view →
LUSC	OS	Quartile	All	0.316	0.483	.013	13	view →
LIHC	OS	Median	III,IV	0.457	0.725	.014	9	view →
ACC	DFS	Median	All	0.178	0.590	.019	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TRADD–LGG (OS)

Open the LGG breakdown →