TPTE

Across TCGA patient cohorts, TPTE mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TPTE-associated genes across cancer lineages are FoxM1, Cyclin-B1, and Lck. Each is linked with TPTE in more than 3 cancer types. Because this analysis shows association rather than direction, both TPTE-to-partner and partner-to-TPTE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TPTE-low versus TPTE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TPTE→partner) and Y-score (partner→TPTE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.223	+1.925	.016	.005	3	4
UCEC	Cyclin-B1 →	+0.612	+2.459	.002	.018	3	3
SKCM	Lck →	-0.383	-2.584	<.001	<.001	3	3
SKCM	cIAP →	+0.120	+2.000	.016	.027	3	2
LUSC	JNK2 →	+0.192	+3.000	.037	.033	3	2
UCEC	G6PD →	-0.230	-1.986	.048	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

FoxM1 by TPTE expression — UCEC

Explore this box plot interactively →