TPTE

Across TCGA pan-cancer cohorts, TPTE RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TPTE’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TPTE RNA is repressed in tumor relative to normal tissue. In most cancer types TPTE is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC, BRCA, and LIHC are the cancer types where TPTE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TPTE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.018	.001	7	view →
BRCA	All	All	+0.041	.007	6	view →
LIHC	All	All	+0.148	.001	4	view →
LUAD	Female	All	+0.064	.023	2	view →
UCEC	All	All	+0.034	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TPTE–KIRC

Open the KIRC breakdown →