TPTE

Across TCGA pan-cancer cohorts, TPTE RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated TPTE data layer compared with 6 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher TPTE RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TPTE expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

MESO, KIRC, and KIRP are the cancer types where TPTE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.183	0.559	<.001	135	view →
KIRC	OS	Quartile	II,III,IV	0.350	0.587	<.001	94	view →
KIRP	OS	Tertile	All	0.389	0.720	<.001	93	view →
COAD	DFS	Tertile	All	0.135	0.573	.001	78	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	45	view →
LUAD	DFS	Tertile	III,IV	0.639	0.242	.007	42	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	33	view →
SKCM	OS	Tertile	All	0.833	0.753	.007	18	view →
CHOL	OS	Tertile	All	0.280	0.816	.002	18	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
UVM	DFS	Tertile	All	0.180	0.744	.019	18	view →
LUSC	OS	Tertile	II,III,IV	0.203	0.587	.009	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

TPTE–MESO (OS)

Open the MESO breakdown →